Explanation

The disease caused by congenital deficiency of thyroxine is Cretinism.

Cretinism is a condition that occurs due to inadequate thyroid hormone production or action, particularly during fetal development or infancy.

Thyroxine, also known as T4, is essential for normal growth and development, including:

• brain development
• Congenital hypothyroidism

Cretinism is characterized by severe:

• physical and mental retardation
• stunted growth
• other developmental abnormalities