| Result | Year | Tournament | Surface | Opponent |
| Win | 2008 | Australian Open | Hard | France Jo-Wilfried Tsonga |
| Win | 2013 | Australian Open | Hard | United Kingdom Andy Murray |
| Win | 2019 | Australian Open | Hard | Spain Rafael Nadal |
| Win | 2020 | Australian Open | Hard | Austria Dominic Thiem |
| Win | 2021 | Australian Open | Hard | Russia Daniil Medvedev |
| Win | 2011 | Australian Open | Hard | United Kingdom Andy Murray |
| Win | 2012 | Australian Open | Hard | Spain Rafael Nadal |
| Win | 2015 | Australian Open | Hard | United Kingdom Andy Murray |
| Win | 2016 | Australian Open | Hard | United Kingdom Andy Murray |
| Loss | 2012 | French Open | Clay | Spain Rafael Nadal |
| Loss | 2014 | French Open | Clay | Spain Rafael Nadal |
| Loss | 2015 | French Open | Clay | Switzerland Stan Wawrinka |
| Win | 2016 | French Open | Clay | United Kingdom Andy Murray |
| Loss | 2020 | French Open | Clay | Spain Rafael Nadal |
| Win | 2021 | French Open | Clay | Greece Stefanos Tsitsipas |
| Loss | 2007 | US Open | Hard | Switzerland Roger Federer |
| Loss | 2010 | US Open | Hard | Spain Rafael Nadal |
| Win | 2011 | US Open | Hard | Spain Rafael Nadal |
| Loss | 2012 | US Open | Hard | United Kingdom Andy Murray |
| Loss | 2013 | US Open | Hard | Spain Rafael Nadal |
| Loss | 2016 | US Open | Hard | Switzerland Stan Wawrinka |
| Win | 2015 | US Open | Hard | Switzerland Roger Federer |
| Win | 2018 | US Open | Hard | Argentina Juan Martín del Potro |
| Win | 2011 | Wimbledon | Grass | Spain Rafael Nadal |
| Loss | 2013 | Wimbledon | Grass | United Kingdom Andy Murray |
| Pending | 2021 | Wimbledon | Grass | Italy Matteo Berrettini |
| Win | 2014 | Wimbledon | Grass | Switzerland Roger Federer |
| Win | 2015 | Wimbledon | Grass | Switzerland Roger Federer |
| Win | 2018 | Wimbledon | Grass | South Africa Kevin Anderson |
| Win | 2019 | Wimbledon | Grass | Switzerland Roger Federer |
