The Amazon in Brazil is _____ longest river in _____ South America.

The Amazon in Brazil is _____ longest river in _____ South America.

Explanation

The sentence mentions the Amazon river in Brazil and its position in South America.

Definite article "the" is used before "Amazon" because it is a specific river that the sentence is referring to.

The indefinite article is not used before "South America" because it is a general reference to the continent, and not a specific one.

Therefore, the correct sentence is "The Amazon in Brazil is the longest river in South America."